Cytology, Histology and Embryology · MU Plovdiv

45. Late development (gastrulation) of human embryo. Formation of the mesoderm and the mesenchyme. Primitive organs.

Inside: 12 sections · 14 labelled pictures · 27 flashcards · 14 min

Topic 45 of 55 in the MU Plovdiv syllabus for Cytology, Histology and Embryology (Dental Medicine, Year 1). The free AceMed note covers it in 11 sections, about 1,890 words (14 min of reading), with 27 flashcards.

In this note

  1. Introduction
  2. Gastrulation
  3. Shaping of the Fetal Body
  4. Mesodermal Differentiation:
  5. Body Folding:
  6. Formation of the Limb Buds:
  7. Formation of the Pharyngeal Arches:
  8. Mesoderm Derivatives
  9. Mesodermal Derivatives: Organ Systems
  10. Mesenchyme:
  11. Mesodermal Development Pathways and Signals

Introduction

The bilaminar embryonic disc is a structure formed early in embryonic development, after fertilization and cleavage have led to the formation of a blastocyst. The disc consists of two layers of cells: the epiblast and the hypoblast.

  • Epiblast: The epiblast is the upper layer of the bilaminar disc and gives rise to all three germ layers during gastrulation (the process where the three primary germ layers—ectoderm, mesoderm, and endoderm—are formed). The epiblast forms the ectoderm (nervous system, skin) and parts of the mesoderm (muscle, bone) and endoderm (digestive and respiratory systems).
  • Hypoblast: The hypoblast is the lower layer and plays a key role in forming structures involved in early development. Although the hypoblast does not give rise to any major tissues in the adult body, it contributes to the formation of the extraembryonic membranes (such as the yolk sac and chorion) and helps in the formation of the embryonic mesoderm. The hypoblast is eventually displaced by the developing endoderm.

The bilaminar disc exists before gastrulation and serves as the foundation for the formation of the trilaminar embryonic disc (the three primary germ layers: ectoderm, mesoderm, and endoderm) that give rise to the entire body.

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