7. Allergy. Terms. Types of allergens. Types of allergic reactions – characteristics, mechanism of tissue damage, diseases and syndromes – examples.

Types of hypersensitivity reaction:

• Transplantation rejection is a manifestation of - cell mediated, immune complex, cytotoxic
• True hypersensitivity = 15-30 mins
• Tuberculin test = anaphylaxis
• Serum markers of drug hypersensitivity and mast cell activation include = Histamine. Tryptase, Bradykinins

1. A. Multiple sclerosis - f/ antibodies against mumps antigens in cerebrospinal fluid and serum, depressed reactions of delayed type hypersensitivity against mumps antigens
2. B. SLE - d/ antibodies against nuclear antigens
3. C. Myasthenia gravis - e/ antibodies against acetylcholine
4. D. Pernicious anemia - a/ autoantibodies against parietal cells of stomach and intrinsic factor and the result of this is no absorption of Vitamin B12
5. E. Hashimoto thyroiditis - b/ autoantibodies against thyroglobulin and thyroid peroxidase
6. F. Hemolytic anemia - c/ antibodies against epitopes of red blood cells