Human Physiology · MU Plovdiv

26. Physiology of the blood. Functions of the blood. Composition and volume of the circulating blood – regulation of the volume. Blood plasma – composition and its regulation. Hemato-crit. Blood reservoirs.

Inside: 2 sections · 5 labelled pictures · 18 flashcards · 5 min

Topic 26 of 80 in the MU Plovdiv syllabus for Human Physiology (Medicine, Year 2). The free AceMed note covers it in 2 sections, about 752 words (5 min of reading), with 18 flashcards.

In this note

  1. Introduction
  2. Blood: functions and properties:

Blood: functions and properties:

  1. Transport:
  2. Oxygen and Carbon Dioxide: Blood carries oxygen from the lungs to the tissues and transports carbon dioxide, a waste product of metabolism, from the tissues back to the lungs for exhalation.
  3. Nutrients and Wastes: It transports nutrients absorbed from the digestive tract to cells throughout the body and carries waste products from cellular metabolism to the kidneys and liver for excretion.
  4. Regulation:
  5. pH Balance: Blood helps regulate the body's acid-base balance using buffer systems that maintain the pH within a narrow range, essential for proper cellular function.
  6. Fluid Volume and Composition: It regulates both the volume and composition of body fluids. This function is critical in maintaining blood pressure and overall fluid balance within the body.
  7. Body Temperature: Blood plays a role in thermoregulation by distributing heat throughout the body and to the skin where heat can be lost to the environment.
  8. Protection:
  9. Immune Function: Blood contains leukocytes (white blood cells) and immunoglobulins (antibodies) that detect and destroy invading pathogens, providing a critical defense mechanism against infections.
  10. Hemocoagulation: Blood has the ability to coagulate, or clot, a vital process that occurs when blood vessels are injured to prevent excessive blood loss. This coagulation process involves platelets, a type of blood cell, and plasma proteins, which form a clot that seals leaks in blood vessels.

Composition of Blood Plasma:

  • Water (Approximately 91%): Serves as the solvent for carrying various substances. The high water content also helps in the regulation of body temperature.
  • Proteins (7%): Includes various proteins like:
  • Albumins: Contribute to plasma's osmotic pressure, helping to regulate the exchange of water between blood and tissues.
  • Globulins: Include immunoglobulins (antibodies) which play a key role in immune responses, and other globulins involved in transport, clotting, and other functions.
  • Fibrinogen: A key clotting factor that is converted to fibrin during the blood clotting process.
  • Other Solutes (1-2%):
  • Electrolytes (e.g., Na+, K+, Ca2+, Mg2+, Cl-, HCO3-): Important for maintaining pH balance, osmotic pressure, and proper nerve and muscle function.
  • Nutrients: Such as glucose, fatty acids, and amino acids that are essential for cellular function.
  • Gases: Including oxygen and carbon dioxide, critical for cellular respiration and metabolic processes.
  • Vitamins and Waste Products: Essential for various biochemical processes and the elimination of metabolic waste.

Functions of Blood Plasma:

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