Internal Diseases – Part 1 (Rheumatology, Pulmonology, Phthisiatrics, Cardiology, Haematology) · MU Plovdiv

1. Pneumonias – pathogenesis , classification, clinical features, differential diagnosis

Inside: 25 sections · 3 labelled pictures · 8 tables · 29 flashcards · 23 min

Topic 6 of 68 in the MU Plovdiv syllabus for Internal Diseases – Part 1 (Rheumatology, Pulmonology, Phthisiatrics, Cardiology, Haematology) (Medicine, Year 4). The free AceMed note covers it in 20 sections, about 2,799 words (23 min of reading), with 29 flashcards.

In this note

  1. Essay 1- Pneumonias- Pathogenesis, Classification, Clinical features. Differential diagnosis
  2. Definition
  3. Classification
  4. Risk factors
  5. Pathogenesis
  6. Symptoms
  7. Physical examination
  8. How to differentiate between pneumonia and other respiratory tract infections
  9. Diagnosis
  10. Scoring
  11. DD
  12. Treatment
  13. Complications
  14. Etiology
  15. Clinical presentation
  16. Assessment of severity
  17. Treatment (overview — details in "Treatment of pneumonias")
  18. Prevention
  19. Hospital-acquired (nosocomial) pneumonia
  20. Pneumonia in immunocompromised patients

Definition

  • Pneumonia is an infection of the lungs caused by bacteria, viruses, fungi and other microorganisms
  • At least 2 of the following symptoms should be present:
  • Fever
  • Chills
  • Cough with or without sputum production
  • Chronic cough with change of sputum colour
  • Pleural pain
  • Breathlessness
  • Signs of lung infiltrate on auscultation
  • New infiltrate on CXR

Classification

Anatomical

  • Lobar pneumonia
  • Consolidation involves all or part of lobe
  • Bronchopneumonia
  • Consolidation involves scattered lobules
  • Develops after bronchitis
  • Interstitial pneumonia
  • Infiltrate involves mainly interstitial tissue between alveoli

Etiological

  • Bacterial:
  • Typical- M.tuberculosis, Streptococcus, Staphylococcus, H.influenzae, K.pneumoniae
  • Gram negative pneumonias are more common in the elderly
  • Atypical- legionella, chlamydia, mycoplasma (they multiply intracellularly)
  • Viral- SARS-CoV-2, RSV, adenovirus, infleunza viruses
  • Fungal- Histoplasma, aspergillus, mucomycosis, blastomyces, candida

Mechanism of acquisition

  • Community acquired pneumonia
  • Hospital acquired pneumonia
  • Aspiration pneumonia
  • Health-care associated pneumonia

Risk factors

  • Age over 65
  • Recent antibiotics
  • Immunocompromised patients
  • Chronic respiratory illness (COPD or asthma)
  • Diabetes mellitus
  • Alcohol abusers
  • Chronic liver and kidney disease
  • Cancer
  • Smokers

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