Pediatrics · MU Sofia

9. Pulmonary pathology in neonatal age.

Covers breathing problems in the newborn, beginning with how the lungs change at birth and the signs of respiratory distress and their severity scores. A table sets out the main conditions by who is affected, the cause, the chest X-ray appearance and treatment, and a second table lists malformations with their clues and first steps. Also discussed are persistent pulmonary hypertension, apnoea of prematurity and bronchopulmonary dysplasia, ending with a stepwise approach to a breathless baby and a brief note on dental effects.

Inside: 8 sections · 2 tables · 16 flashcards · 4 min

Topic 9 of 30 in the MU Sofia syllabus for Pediatrics (Medicine, Year 5). The free AceMed note covers it in 8 sections, about 297 words (4 min of reading), with 16 flashcards.

In this note

  1. Introduction
  2. Signs of respiratory distress in a newborn
  3. The main conditions
  4. Persistent pulmonary hypertension of the newborn (PPHN)
  5. Apnoea of prematurity
  6. Bronchopulmonary dysplasia
  7. Malformations that cause breathing problems
  8. How to approach a breathless newborn

Introduction

At birth the lungs must change in seconds from fluid-filled organs to air-filled ones: the fluid is absorbed, the alveoli open and pulmonary blood flow rises eight-fold. Breathing problems in the newborn come from failure of this change, from immaturity, or from malformations.

Signs of respiratory distress in a newborn

Tachypnoea over 60/min, nasal flaring, grunting (breathing out against a partly closed glottis to keep the alveoli open), intercostal and subcostal recession, see-saw breathing, cyanosis, apnoea. Severity is scored with the Silverman–Andersen or Downes score.

Persistent pulmonary hypertension of the newborn (PPHN)

Pulmonary vascular resistance stays high after birth, so blood bypasses the lungs right-to-left through the foramen ovale and ductus. Seen with meconium aspiration, asphyxia, sepsis, diaphragmatic hernia or alone. Severe cyanosis, with pre-ductal (right hand) saturation higher than post-ductal (foot). Echo confirms. Treatment: oxygen, ventilation, inhaled nitric oxide, support the blood pressure, ECMO if all fails.

Apnoea of prematurity

Pauses in breathing of 20 seconds or more (or shorter with bradycardia or desaturation) from an immature respiratory centre, in babies under 34 weeks. Exclude sepsis, hypoglycaemia, seizures, anaemia. Treatment: gentle stimulation, caffeine citrate, CPAP.

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