Topic 27 of 63 in the MU Plovdiv syllabus for Biochemistry (Dental Medicine, Year 2). The free AceMed note covers it in 18 sections, about 1,343 words (10 min of reading), with 20 flashcards.
In this note
Fatty Acid Biosynthesis
BIOSYNTHESIS OF FATTY ACIDS
ACETYL-COA CARBOXYLASE
FATTY ACYL SYNTHASE – MULTIFUNCTIONAL ENZYME
REGULATION OF FATTY ACID BIOSYNTHESIS
MCQS
ANSWERS
Differences Between Saturated and Unsaturated fatty acids
Saturated vs Unsaturated Fatty Acids
Omega-3 vs Omega-6 Fatty Acid
Desaturation of Fatty Acids
Deficit of Essential Fatty Acids
Eicosanoids – Major Classes and Biological Role
Catabolism and Biosynthesis of Triacylglycerols
Hormone Sensitive Lipase
Metabolism of Glycerol
MCQs ☺
Answers
Fatty Acid Biosynthesis
ABC Carboxylase Rxns
Malonyl CoA formation
Gluconeogenesis
Odd chain fatty acid oxidation
Fatty Acid Biosynthesis
1ˢᵗ condensation rxn = 4C
6 increments x 2C = 12C
Palmitate 16C
BIOSYNTHESIS OF FATTY ACIDS
Fatty acid biosynthesis is an anabolic process building fatty acids from acetyl-CoA and malonyl-CoA precursors through a series of enzymatic reactions. It predominantly occurs in the cytosol of liver and adipose cells in humans.
Initiation:
Begins with the carboxylation of acetyl-CoA to form malonyl-CoA.
This reaction is catalyzed by acetyl-CoA carboxylase, a key regulatory step in fatty acid synthesis.
Elongation:
The elongation cycle adds two carbons from malonyl-CoA to a growing fatty acid chain.
Each cycle consists of condensation, reduction, dehydration, and a second reduction, ultimately extending the chain by two carbon atoms.
The cycles are catalyzed by the enzyme complex fatty acid synthase.
Termination:
The elongation process continues until the fatty acid reaches a typical length of 16 carbons (palmitate), which is then released.
Continue reading free
The whole note, all 18 sections, is free with an AceMed account, with its 20 flashcards. Premium adds flashcard recall, highlights and Ask AI.
