Pathophysiology · MU Plovdiv

62. Disorders in sleep and wakefulness – central and obstructive sleep apnea.

Inside: 8 sections · 4 labelled pictures · 12 flashcards · 3 min

Topic 62 of 63 in the MU Plovdiv syllabus for Pathophysiology (Medicine, Year 3). The free AceMed note covers it in 8 sections, about 373 words (3 min of reading), with 12 flashcards.

In this note

  1. Sleep Apnoea
  2. Definition
  3. Classification:
  4. Predisposing Factors:
  5. Mechanism:
  6. Symptoms:
  7. Diagnosis:
  8. Severity classification (based on Apnoea-Hypopnoea Index - AHI):

Definition

Sleep apnoea is a sleep disorder characterized by repeated episodes of paused (apnoea) or shallow breathing (hypopnoea) during sleep. These interruptions may last from a few seconds to minutes and can occur dozens to hundreds of times a night. Most commonly, it is associated with loud snoring, and as normal breathing resumes, patients may make choking or gasping sounds.

Classification:

  1. Obstructive Sleep Apnoea (OSA) – Most common type
  • Caused by partial or complete obstruction of the upper airway during sleep.
  • Breathing effort is present but ineffective due to the blockage.
  • Often leads to intermittent hypoxia and fragmented sleep.
  1. Central Sleep Apnoea (CSA)
  • Results from a failure in the brain's respiratory control centers to send proper signals to the breathing muscles.
  • No respiratory effort is made during the pause.
  • Commonly seen in older adults and those with heart conditions or neurological disease.
  1. Mixed Type
  • Features of both OSA and CSA.
  • Begins as central apnoea but ends with obstruction.

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