PERIPHERAL NERVES
- A peripheral nerve is a bundle of nerve fibers (axons) held together by connective tissue.
Development of PN:
- Peripheral nerves originate from neural crest cells.
- 1. Neural Crest cells (NCS) seperate from the neural tube, and migrate to various regions of the embry, where they differentiate into different cell types, including neurons & glial cells of the PNS.
- 2. Differentiated neurons extend axons & dentrites to establish connections with target cells, forming the basis of PN.
- 3. Schwan cells wrap around axons to form myelin seaths, wich increase the speed & efficiency of nerve impulse conduction.
- 4. Multiple nerve fibers bundle together to form nerve fascicles, which are surrounded by connective tissue layers called perineurium.
- 5. Perineurial cells secrete extracellular matrix components that provide structural support and organization to nerve fascicles.
Regional Innervation:
- Peripheral nerves have a different distribution pattern compared to spinal nerves.
Dermatomes
- 1. Definition:
- A dermatome is an area of skin supplied by sensory fibers from a specific spinal nerve.
- 2. Dermatome Maps:
- These maps show the approximate areas of skin supplied by each spinal nerve.
- There is considerable overlap between adjacent dermatomes.
- 3. Axial Lines:
- Areas where there is little overlap between the skin areas served by non-contiguous spinal nerves.
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Myotomes
- 1. Definition:
- A myotome is a group of muscles innervated by the motor fibers of a particular spinal nerve.
- 2. Functionality:
- These muscles are usually functionally related and responsible for specific patterns of movement.