96. Family Adenoviridae | Genus Papillomavirus | Genus Polyomavirus
Covers three DNA virus groups in sequence: adenoviruses, with their stability, transmission, receptor-mediated pathogenesis and a range of clinical syndromes, then papillomaviruses, including a low-risk versus high-risk classification table, the E6 and E7 oncoprotein mechanisms, koilocyte cytology and HPV vaccines. It closes with polyomaviruses (JC and BK), presented in a comparison table, with their PML and nephropathy features and diagnostic approaches.
Topic 96 of 113 in the MU Sofia syllabus for Microbiology (Dental Medicine, Year 2). The free AceMed note covers it in 4 sections, about 424 words (4 min of reading), with 15 flashcards.
In this note
Family Adenoviridae | Genus Papillomavirus | Genus Polyomavirus
I. Family Adenoviridae
II. Genus Papillomavirus
III. Genus Polyomavirus
I. Family Adenoviridae
A. General Characteristics
Non-enveloped, icosahedral, double-stranded DNA virus
Linear dsDNA genome
Replicates in the nucleus
Stable in environment (acid, ether resistant)
Infects respiratory tract, GI tract, conjunctiva, and urinary tract
Transmission: fecal-oral, respiratory droplets, direct contact, swimming pools
B. Pathogenesis
Virus binds to host cell via coxsackie-adenovirus receptor (CAR)
Internalized → uncoating in nucleus → replication via host DNA-dependent polymerase
Lytic or latent infection (especially in lymphoid tissues like adenoids and tonsils)
Inflammation and necrosis of epithelial cells → tissue-specific disease
C. Clinical Features
Pharyngoconjunctival fever (children):
Conjunctivitis + pharyngitis + fever
Acute respiratory disease (military recruits)
Gastroenteritis: types 40, 41 cause diarrhea (esp. children)
Hemorrhagic cystitis: hematuria in children (types 11, 21)
