58. Humoral immunity changes in rheumatic diseases
Explains how humoral immunity underlies many rheumatic diseases, with plasma cells producing autoantibodies against autoantigens. Gives a list pairing each disease with its characteristic antibody, including anti-dsDNA, anti-Sm, anti-Ro, anti-topoisomerase 1, anti-centromere, anti-SRP, ANCA subtypes and rheumatoid factor. Two immunofluorescence images illustrate the perinuclear p-ANCA and granular cytoplasmic c-ANCA patterns.
Topic 58 of 139 in the MU Sofia syllabus for Internal Diseases and Therapy (Medicine, Years 4 and 5). The free AceMed note covers it in 1 section, about 127 words (1 min of reading), with 14 flashcards.
In this note
Humoral immunity changes in rheumatic diseases
Humoral immunity changes in rheumatic diseases
Lots of rheumatic diseases have their bases in the humoral immune system. Plasma cells produce specific antibodies which act as autoantibodies, directed against autoantigens. Below we have listed some of the important antibodies for specific diseases:
