11. Malignant tumors of the breast - clinical picture, classification, staging and complex treatment · Nuclear Medicine · MU Sofia

11. Malignant tumors of the breast - clinical picture, classification, staging and complex treatment.

Covers treatment approaches for lung cancer, namely lung cancer rather than breast cancer, including surgery (lobectomy for most non-small cell cases), radiotherapy, chemotherapy with cisplatin and etoposide, and targeted therapies with tyrosine kinase inhibitors and a monoclonal antibody. It is not about breast tumours.

Inside: 1 section · 14 flashcards · 1 min

Topic 44 of 50 in the MU Sofia syllabus for Nuclear Medicine (Medicine, Year 4). The free AceMed note covers it in 1 section, about 172 words (1 min of reading), with 14 flashcards.

Approaches for treatment of common lung cancer

Treatment depends on type, spread, patient status. Treatments include palliative care, surgery, chemotherapy and radiation therapy. Targeted therapy is becoming more prevalent as well.

Surgery

In most cases of NSCLC a lung lobectomy is the surgical treatment of choice
In SCLC Chemotherapy/radiotherapy is more typically used

Radiotherapy

Often given with chemotherapy. Curative in NSCLC patients where surgery is not an option (second line). SHOULD NOT BE USED AS ADJUVANT THERAPY FOR CURATIVE NSCLC SURGERY.
For SCLC cases, radiotherapy and chemotherapy is first line treatment, external beam radiotherapy is the recommended course of action
Low dose radiotherapy is given for palliative care in both cancer forms

Chemotherapy

SCLC commonly uses chemotherapy combination cisplatin and etoposide + radiotherapy at all stages
In NSCLC adjuvant chemotherapy improves survival by 4% at five years for stage II or more. Stage I there is limited evidence of chemotherapy being useful

Targeted therapy

Several targeted therapies include: Erlotinib + gefitinib (tyrosine kinase inhibitors). Denosumab (monoclonal antibody) - tumor must have EGFR or ALK mutations for this to wokr.