4. Follow-up of cancer patients. Symptomatic and palliative treatment. Pain treatment.
Explains why nausea and vomiting are so common with chemotherapy, since the drugs hit fast-dividing cells, and why antiemetic treatment matters for tolerating treatment. Lists the main antiemetics: serotonin antagonists such as ondansetron, granisetron and palonosetron, plus dexamethasone, metoclopramide and haloperidol, with brief notes on how some act.
Inside: 1 section · 9 flashcards · 1 min
Topic 37 of 50 in the MU Sofia syllabus for Nuclear Medicine (Medicine, Year 4). The free AceMed note covers it in 1 section, about 92 words (1 min of reading), with 9 flashcards.
In this note
Antiemetic therapy - principles of GI toxicity treatment
Antiemetic therapy - principles of GI toxicity treatment
Emesis (vomiting) is one of the most common side effects of chemotherapeutics. That is because these drugs act disproportionately on dividing cells, and more of these are found in the gastrointestinal system than many other systems. The extent of the emesis due to GI irritation can make the chemotherapy intolerable, as such, antiemetic therapy forms an important part of chemotherapy. We have listed below the main drugs:
Serotonin antagonists
Ondansetron, Granisetron, Palonosetron
Dexamethasone (unclear mechanism, is a corticosteroid, but it just works!)
Metoclopramide (blocks dopamine and serotonin receptors)
Haloperidol (blocks dopamine receptors)
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