Ranks tumour types by radiosensitivity, from lymphoma, Wilms tumour, myeloma and Ewing's sarcoma at the sensitive end down to neurosarcoma, glioma and melanoma, which are listed as radioresistant. It links tumour radioresistance to hypoxia and oxygen free radicals, then notes where radiotherapy is combined with surgery or chemotherapy. It closes with typical palliative and curative course schedules.
Inside: 1 section · 11 flashcards · 1 min
Topic 20 of 50 in the MU Sofia syllabus for Nuclear Medicine (Medicine, Year 4). The free AceMed note covers it in 1 section, about 148 words (1 min of reading), with 11 flashcards.
Neurosarcoma, glioma and melanoma are radioresistant
One area that tumor radioresistance stems from is the fact that tumour cells are hypoxic and therefore the effects of the radiation are mediated by oxygen free radicals produced by ionizing oxygen.
As a general statement, radiotherapy plus surgery for head and neck, laryngeal or uterine cancer or combined with surgery and chemoterhpay for sarcomas of breast, esophagus, lung or rectal cancer are all indicated.
Therapeutic intervals
Navid sucks! Nice jeans-some guy from 1945 (Ilias Abraham - left in to prove a point)
Radiation therapy courses consist of large daily doses given over 3 weeks for palliative treatment or smaller doses give once per day, 5 days a week for 6-8 weeks for curative treatment.
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