Ophthalmology · MU Sofia

58. Uveal tumours

Covers treatment options for uveal tumours, starting with brachytherapy for lesions under 10 mm in elevation and alternatives such as transpupillary thermotherapy, external beam radiotherapy and enucleation. It then describes how malignant melanoma of the ciliary body spreads anteriorly, posteriorly or circumferentially, with the distinct signs each pattern produces, including secondary glaucoma. Iris tumours follow, contrasting the common pigmented naevus with a rapidly growing vascular melanoma and its treatment.

Inside: 1 section · 3 labelled pictures · 13 flashcards · 2 min

Topic 58 of 91 in the MU Sofia syllabus for Ophthalmology (Medicine, Year 4). The free AceMed note covers it in 1 section, about 234 words (2 min of reading), with 13 flashcards.

In this note

  1. Treatment

Treatment

Brachytherapy (internal radiotherapy) is the treatment of choice if tumour is less than 10 mm in elevation and other techniques include Transpupillary thermotherapy and external beam radiotherapy as well.

Enucleation is the final step alongside chemotherapy for metastasised tumours.

Malignant melanoma of ciliary body

Diagnosed very late as it is hidden; it can extend anteriorly, posteriorly or grow circumferentially thereby causing specific presentations each.

In early stage it is localised and affects the ciliary body only leading to hypotony and defective vision + localised Episcleral vein dilatation.

It can appear as a structure pushing the iris edges inwards

If it grows anteriorly it causes damages to the lens such as cataract, subluxation or anterior displacement as well as involving the iris which is immediately visible and this all leads to secondary glaucoma .

If it grows posteriorly then choroidal damage and signs will be apparent as well as exudate retinal detachment.

Usually it is treated by enucleation of if it is detected in time resection of ciliary body alone or + affected structures.

Tumours of the iris

Most common lesion of iris= Naevus which is a flat, pigmented circumscribed lesion of different sizes and it can become malignant

Malignant melanoma is presented as a vascular nodule/nodules growing rapidly which can spread into the angle producing secondary glaucoma or penetrate the limbus

It can be treated with Ectomy of Iris and affected structures or enucleation.

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