Medicine · Year 5 · MU Sofia

Clinical Pharmacology

In Year 5 of Medicine at the Medical University of Sofia, the Clinical Pharmacology syllabus spans 30 topics. It opens with evidence-based medicine and clinical pharmacokinetics, including volume of distribution, half-life, steady state and therapeutic drug monitoring, then covers clinical drug trials, their design, phases, ethics and bioequivalence, followed by EU drug regulation, renal and hepatic failure, adverse drug reactions and pharmacovigilance, drug interactions and pharmacoeconomics. It closes with rational antibiotic prescribing and prescribing in hypertension, heart failure, ischaemic heart disease, type 2 diabetes and asthma. AceMed's notes are short, about an hour of reading in all, and are built on 44 tables rather than pictures, with 465 flashcards.

The full MU Sofia syllabus for Clinical Pharmacology, Medicine, Year 5: 30 topics, every one with a free study note (66 minutes of reading), and 465 flashcards. Updated 2 November 2026.

syllabus topics: 30
free notes: 30
flashcards: 465
of reading: 66 min

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Syllabus

The topics in the order of the MU Sofia syllabus. Each one with a note opens in AceMed once you're signed in.

1. Sources of unbiased medical information - Evidence Based Medicine (EBM): Definition, Class recommendation and Levels of evidence. Application in clinical practice.3 min · 16 cards
2. Clinical pharmacokinetics: application of the parameters "volume of distribution" and "plasma protein binding" of drugs in clinical practice.3 min · 16 cards
3. Clinical pharmacokinetics: application of the parameter "terminal half life" of drugs in clinical practice.2 min · 15 cards
4. Clinical pharmacokinetics: application of the parameter "steady state plasma concentrations" of drugs in clinical practice.2 min · 15 cards
5. Therapeutic Drug Monitoring (TDM): Definition, types. Application in clinical practice.2 min · 15 cards
6. Clinical Drug Trials: types, design, phases. Approaches for reducing external sources of bias: placebo, randomization.3 min · 16 cards
7. Clinical Drug Trials: ethical and regulatory requirements. Good Clinical Practice (GCP).2 min · 15 cards
8. Clinical Drug Trials: evaluation of the bioavailability and bioequivalence of drugs.2 min · 15 cards
9. Clinical Drug Trials - Phase 1: Design, target population, aims.2 min · 15 cards
10. Clinical Drug Trials - Phase 2: Design, target population, aims.2 min · 14 cards
11. Clinical Drug Trials - Phase 3: Design, target population, aims.2 min · 15 cards
12. Clinical Drug Trials - Phase 4: Design, target population, aims.2 min · 15 cards
13. Drug regulation. Registration of drug use in the EU.2 min · 16 cards
14. Illness as a factor modifying drug action: Impact of chronic renal failure and chronic hepatic failure.2 min · 16 cards
15. Adverse Drug Reactions (ADRs) - Definition, types. Importance for clinical practice.2 min · 15 cards
16. Adverse Drug Reactions - Definition. Yellow card system for reporting ADRs.2 min · 15 cards
17. Adverse Drug Reactions - Definition. Methods for detection. Pharmacoepidemiology.3 min · 16 cards
18. Drug interactions. Types. Importance for clinical practice.2 min · 15 cards
19. Pharmacoeconomics: Definition, principles: perspective, duration, modeling, compliance.3 min · 15 cards
20. Pharmacoeconomics: Definition. Types of pharmacoeconomic analyses.2 min · 16 cards
21. Principles of rational antimicrobial drug prescribing. Efficacy criteria. Algorithm for antibacterial drug choice.3 min · 16 cards
22. Principles for combined antibacterial drug prescribing.2 min · 15 cards
23. Principles of prophylactic prescribing of antibacterial drugs in surgical practice.2 min · 16 cards
24. Rational drug prescribing in patients with urinary tract infections.2 min · 16 cards
25. Rational drug prescribing in patients with pneumonia.2 min · 16 cards
26. Rational drug prescribing in patients with essential hypertension.2 min · 16 cards
27. Rational drug prescribing in patients with chronic heart failure.2 min · 15 cards
28. Rational drug prescribing in patients with ischemic heart disease.2 min · 17 cards
29. Rational drug prescribing in patients with type-2 diabetes.2 min · 16 cards
30. Rational drug prescribing in patients with bronchial asthma.2 min · 16 cards

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